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For a better explanation, watch this video. Do not confuse this with a tier list for cards or relics, as this data may be skewed by many different factors. Spire Logs - Contains data on player's past runs.

Reference Sheet - A handy spreadsheet containing information on every aspect of the game, including enemy attack patterns. Official Discord Server - Join us to chat, discuss strategies, share memes, and more! Now all you need to do is sit back and watch the chaos.Dedicated to all discussion on the game Slay the Spire by Mega Crit Games. Now get All of the Genetic Reshuffle (1,2 and 3). Now the death rate skyrockets, and you'll have a steady income of DNA points. After getting enough DNA points get Necrosis and Hemorrhagic Shock. Now your main objective is to get to Total Organ Failure first. Now save up your DNA points till you infect everyone in the world or the message 'There are no more healthy people left in the world' pops up. Devolve any lethal symptom if it mutates. Now keep in mind that you should NOT evolve ANY symptoms as it'll lead to either people dying faster or your parasite getting detected faster. Now wait till you get 50 or more DNA points so that you can get Drug Resistance 2 and Genetic Hardening 1. Its also useful so you can afford to play powers and defense on the same turn, which is ordinarily an issue with power decks. Its great with Dead Branch or some of the other exhaust synergies. Then your parasite could mutate a few symptoms, but don't bother. Daily Discussion/Debate 175 - Seeing Red (Ironclad Uncommon) Gain 2 Energy. This will ensure that your parasite will not be detected, and then get Air 1 & 2, Water 1 and if you have any points left and you can afford it, Drug Resistance 1. Wait till you get like 50 DNA points, then completely evolve the symbiosis to level 3. This'll make things easier later in the game. By the way, in the beginning, if you have unlocked the gene for bonus DNA when devolving, then use it. Please note that using this method you'll have to play in fast forward, as you'll usually win in 900 days or more depending on how fast you evolve things. Firstly, start in a hot country, so that all other hot countries con be infected in due time. Immediately after that I decided to try my own method. The first time I tried this, I followed everything step by step and 'Shit' got detected to early and I lost, with Greenland infected but majorly healthy. Oh and make sure you use drug resistance and genetic hardening.ĭid not work, to fix: before you go for total organ failure (I didn't even get to it for a really long time and would recommend going there from coughing) get your points to 100, also devolve all symptoms until u infect everyone in the world As long as you make sure every last human is infected before any symptoms are evolved, you should be good. Instead of using points on transmission, I evolved all three symbiosis first, early in the game. I won the game by devolving any mutations until everyone was infected. so i did genetic reshuffle 1 and i killed evryone These must be very hard to make, VV as said below too Thanks for your efforts put into this webpage/walkthrough. 1023 days 79% cure I had to get the DNA looking things to throw the cure back to around 60-65 percentage (%) Otherwise cure would have won! :D Thanks for carrying me through the whole game! I don't have many things left now.

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